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Cis-trans dynamical asymmetry in driven polymer translocation.

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Polymer translocation through nanopores involves distinct pulling (fast diffusion) and pushing (slow diffusion) dynamics. This study explains the observed cis-trans asymmetry by matching continuum solutions, revealing how driving force is allocated.

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Area of Science:

  • Polymer Physics
  • Nanopore Science
  • Statistical Mechanics

Background:

  • Polymer translocation through nanopores is crucial for applications like DNA sequencing.
  • Observed dynamical asymmetry between cis (entry) and trans (exit) sides requires theoretical explanation.
  • Continuum models describe polymer dynamics, but reconciling cis-trans behavior is challenging.

Purpose of the Study:

  • To provide a physical basis for the dynamical asymmetry in polymer translocation.
  • To model the interplay between pulling and pushing forces during translocation.
  • To predict the allocation of driving force between the cis and trans sides.

Main Methods:

  • Utilizing continuum-level descriptions of polymer transport.
  • Applying nonlinear transport processes: fast diffusion (cis) and slow diffusion (trans).
  • Matching solutions across the nanopore using mass conservation principles.

Main Results:

  • Established a physical basis for the cis-trans dynamical asymmetry observed in simulations.
  • Predicted the dynamic allocation of the total driving force between cis and trans sides.
  • Demonstrated that trans-side dynamics introduce a finite-chain length effect on dynamical scaling.

Conclusions:

  • The theoretical framework explains the observed asymmetry in polymer translocation dynamics.
  • Understanding force allocation is key to controlling translocation processes.
  • Finite-chain effects in the trans side influence overall translocation scaling.