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Does corticosterone affect gastric mucosal cell growth during development?

C C Tseng, L R Johnson

The American Journal of Physiology

|May 1, 1986

Summary

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Corticosterone precociously induced pepsinogen in developing gastric mucosa but did not stimulate growth. These developmental effects of corticosterone were transient, resolving by day 25.

Area of Science:

Developmental biology
Gastroenterology
Endocrinology

Background:

Corticosterone influences physiological development.
Gastric mucosa development is crucial for digestive function.
Pepsinogen appearance indicates functional maturation of oxyntic glands.

Purpose of the Study:

To investigate the impact of corticosterone on gastric mucosa growth during development.
To assess whether corticosterone affects pepsinogen content and acid output.
To determine if corticosterone-induced precocious development involves growth stimulation.

Main Methods:

Assessing gastric mucosa weight, DNA, RNA, and protein content.
Measuring pepsinogen content in the oxyntic gland.
Evaluating basal acid output in corticosterone-treated and control animals.

Related Experiment Videos

Monitoring body weight changes during postnatal development.

Main Results:

Corticosterone treatment led to transiently lower body weights.
Precocious pepsinogen appearance and increased basal acid output were observed.
These effects diminished by day 25.
Gastric mucosa weight and cellular components (DNA, RNA, protein) increased with age but were unaffected by corticosterone.

Conclusions:

Corticosterone induces precocious functional development of the gastric mucosa.
This induction is not mediated by stimulating gastric mucosal growth.
The observed effects of corticosterone on gastric development are temporary.