Related Experiment Video
Updated: May 6, 2026
08:00
Sample Preparation and Relative Quantitation using Reductive Methylation of Amines for Peptidomics Studies
Published on: November 4, 2021
1.9K
Food-derived bioactive peptides--a new paradigm
Paul J Moughan1, Shane M Rutherfurd1, Carlos A Montoya1
1Riddet Institute, Massey University,Private Bag 11-222,Palmerston North,New Zealand.
Nutrition Research Reviews
|November 16, 2013
Summary
Food proteins yield variable bioactive peptides in the gut. Gut endogenous proteins, however, offer a consistent source of these important physiological modulators, suggesting a previously unrecognized role.
Area of Science:
- Gastroenterology
- Molecular Biology
- Nutrition Science
Background:
- Bioactive peptides from food modulate physiological processes in the gastrointestinal tract (GIT).
- Concentrations of food-derived bioactive peptides are highly variable due to dietary protein intake.
- Gut endogenous proteins represent a consistent and significant potential peptide source in the GIT.
Purpose of the Study:
- To investigate the potential role of gut endogenous proteins as a source of bioactive peptides.
- To evaluate the significance of gut endogenous proteins in modulating GIT physiology.
Main Methods:
- The study proposes a hypothesis based on existing knowledge of protein digestion in the GIT.
- Literature review and theoretical analysis of protein sources and digestion.
Main Results:
- Up to 80% of gut endogenous proteins are digested, generating a wide range of peptides.
- Food-derived bioactive peptides are variable, unlike endogenous sources.
Conclusions:
- Gut endogenous proteins may play a significant, previously unrecognized role as a consistent source of bioactive peptides in the GIT.
- This highlights a potential new area for understanding peptide-mediated physiological regulation within the gastrointestinal tract.
Related Concept Videos
01:02Protein Digestion
86.5K
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
86.5K
01:33Peptide Identification Using Tandem Mass Spectrometry
6.2K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.2K
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
361
Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
361
01:33Proteomics
7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.5K
01:20The Central Dogma
21.2K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
21.2K