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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Abnormal cingulum bundle development in autism: a probabilistic tractography study.

Toshikazu Ikuta1, Keith M Shafritz2, Joel Bregman3

  • 1Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA; Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY 11004, USA.

Psychiatry Research
|November 16, 2013
PubMed
Summary
This summary is machine-generated.

Autism Spectrum Disorder (ASD) shows atypical white matter development, specifically in the cingulum bundle. This impacts executive functions, with lower white matter integrity linked to poorer regulation skills in adolescents and young adults.

Keywords:
Autism spectrum disorderDevelopmentDiffusion tensor imagingWhite matter

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Autism Research

Background:

  • White matter abnormalities are implicated in autism neurobiology.
  • Limited research exists on white matter development in autism and its link to neurocognitive deficits.

Purpose of the Study:

  • To investigate white matter development in the cingulum bundle in adolescents and young adults with Autism Spectrum Disorder (ASD).
  • To examine the relationship between cingulum white matter integrity and executive functioning in ASD.

Main Methods:

  • Probabilistic tractography used to identify the cingulum bundle in 21 adolescents/young adults with ASD and 21 controls.
  • Fractional anisotropy (FA) measured as an indicator of white matter integrity.
  • Explored group differences in age-FA relationships and correlation with executive function (BRIEF).

Main Results:

  • ASD participants showed significantly lower fractional anisotropy (FA) in the cingulum bundle compared to controls.
  • A group-by-age interaction revealed ASD individuals lacked typical age-related FA increases.
  • Lower cingulum FA correlated with poorer executive function (Behavior Rating Inventory of Executive Function - BRIEF) scores in ASD.

Conclusions:

  • Findings suggest dysregulated cingulum bundle white matter development in late adolescence/early adulthood in ASD.
  • Greater disruptions in this developmental trajectory are associated with executive dysfunction in ASD.
  • Highlights the role of specific white matter pathways in ASD-related neurodevelopmental and cognitive challenges.