Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 6, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Self-assembling of large ordered DNA arrays using superhydrophobic patterned surfaces.

G Ciasca¹, L Businaro, M Papi

¹Istituto di Fisica, Universitá Cattolica SC, L.go Francesco Vito 1 I-00168, Roma, Italy.

|November 16, 2013

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Near-term extrauterine pregnancy secondary to uterine rupture in a mare.

Journal of equine veterinary science·2026

Same author

Towards quantitative MRI Driving online adaptive MRgRT for lung tumors.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026

Same author

A meta-analysis on use of agro-industrial by-products rich in polyphenols in dairy small ruminant nutrition.

Animal : an international journal of animal bioscience·2025

Same author

What is the "train track" in the retained equine testis?

Journal of equine veterinary science·2025

Same author

Transforming personalized weight forecasting: From the Personalized Metabolic Avatar to the Generalized Metabolic Avatar.

Computers in biology and medicine·2025

Same author

Exploring novel circulating biomarkers for liver cancer through extracellular vesicle characterization with infrared spectroscopy and plasmonics.

Analytica chimica acta·2024

Researchers developed a simple method using superhydrophobic surfaces to create ordered arrays of stretched DNA molecules. This technique precisely positions DNA strands, paving the way for advanced DNA chips for genetic analysis.

Area of Science:

Materials Science
Biotechnology
Nanotechnology

Background:

Developing methods for precise DNA molecule manipulation is crucial for advancing genetic analysis and nanotechnology.
Existing techniques often face challenges in achieving large-scale, ordered arrangements of DNA.

Purpose of the Study:

To present a simple, robust method for creating highly ordered, millimeter-scale arrays of stretched and suspended DNA molecules.
To enable precise positioning of DNA strands for potential applications in DNA chips.

Main Methods:

Utilized a custom-designed superhydrophobic surface composed of high aspect-ratio silicon pillars.
Deposited genomic DNA droplets onto the surface, controlling de-wetting dynamics through pillar shaping.
Incorporated sharpened features on silicon pillars to precisely pin DNA strands.

More Related Videos

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Published on: January 6, 2016

Simple, Affordable, and Modular Patterning of Cells using DNA

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Related Experiment Videos

Last Updated: May 6, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Published on: January 6, 2016

Simple, Affordable, and Modular Patterning of Cells using DNA

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Main Results:

Achieved highly ordered arrays of stretched and suspended DNA molecules at the millimeter length scale.
Demonstrated precise positioning and suspension of individual DNA strands above silicon pillars.
The controlled de-wetting dynamics facilitated accurate DNA strand placement.

Conclusions:

The developed technique offers a simple and robust approach for large-scale DNA molecule patterning.
This method holds significant potential for the development of novel DNA chips for genetic analysis.
The precise control over DNA molecule arrangement opens avenues for advanced molecular diagnostics.