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Updated: May 6, 2026

Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
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Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

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702

[Epigenetics as a novel therapeutic target of cancer]

Toshikazu Ushijima1, Hideyuki Takeshima

  • 1Division of Epigenomics, National Cancer Center Research Institute.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|November 16, 2013
PubMed

Insights

Epigenetic therapies offer a promising new avenue for cancer treatment, targeting abnormalities in gene expression. Research highlights the importance of personalized approaches for effective application in solid tumors, particularly non-small cell lung cancer.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Context:

  • Epigenetic abnormalities play a crucial role in carcinogenesis and persist through cell division.
  • Cancer genome analyses reveal frequent mutations in epigenetic genes, beyond protein-coding genes.
  • Approved epigenetic drugs include DNA demethylating agents and histone deacetylase inhibitors.

Purpose:

  • To review the current landscape and future potential of epigenetic therapies in cancer treatment.
  • To highlight the significance of epigenetic gene mutations in cancer development.
  • To discuss the application and promising results of epigenetic therapies in solid tumors.

Summary:

  • Epigenetic therapy is emerging as a key strategy alongside molecularly targeted drugs.
  • Mutations in epigenetic genes are common in cancers not explained by protein-coding gene mutations.
  • Next-generation epigenetic drugs are in development, with promising results seen in non-small cell lung cancers.

Impact:

  • Epigenetic therapies represent a significant advancement in cancer treatment strategies.
  • Understanding epigenetic mechanisms is crucial for developing effective cancer therapies.
  • Personalized approaches (right patient, dose, combination) are essential for maximizing the success of epigenetic treatments.

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