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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

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Coxsackievirus A16: epidemiology, diagnosis, and vaccine

Qunying Mao1, Yiping Wang1, Xin Yao1

  • 1National Institutes for Food and Drug Control; Beijing, PR China.

Human Vaccines & Immunotherapeutics
|November 16, 2013
PubMed

Insights

Coxsackievirus 16 (CA16), a cause of hand, foot, and mouth disease (HFMD), is increasingly linked to severe cases and co-infections with EV71. Research now focuses on CA16

Area of Science:

  • Virology
  • Public Health
  • Infectious Diseases

Background:

  • Coxsackievirus 16 (CA16) is a primary cause of hand, foot, and mouth disease (HFMD) in children.
  • CA16 and enterovirus 71 (EV71) co-circulation in the Western Pacific presents a significant public health challenge.
  • While typically mild, CA16 infections are now associated with severe and fatal outcomes.

Purpose of the Study:

  • To investigate the evolving clinical and virological characteristics of CA16.
  • To understand the impact of CA16 and EV71 co-infections on disease severity and epidemiology.
  • To guide the development of diagnostic tools and vaccines for CA16.

Main Methods:

  • Review of recent epidemiological data on CA16 and EV71 outbreaks.
  • Analysis of clinical case reports detailing severe CA16 infections.
  • Examination of studies on viral co-infection and genetic recombination.

Main Results:

  • CA16 is implicated in an increasing number of severe and fatal HFMD cases.
  • Co-infection with EV71 exacerbates central nervous system complications.
  • Genetic recombination between CA16 and EV71 may drive large-scale outbreaks, as seen in China in 2008.

Conclusions:

  • CA16 poses a growing threat beyond its traditionally mild presentation.
  • Understanding CA16-EV71 interactions is crucial for managing HFMD outbreaks.
  • Further research into CA16 virology is essential for effective control strategies.

Keywords:
Coxsackievirus A16 (CA16)animal modelneutralizing antibodyrecombinationvaccine

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