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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Production of Formed Elements01:34

Production of Formed Elements

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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
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Developmental changes in hematopoietic stem cell properties.

Michael R Copley1, Connie J Eaves

  • 1Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada.

Experimental & Molecular Medicine
|November 16, 2013
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) maintain lifelong blood production through self-renewal. The Lin28b-let-7 pathway regulates HSC changes, impacting clinical applications and leukemia pathogenesis.

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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Hematopoietic stem cells (HSCs) are crucial for continuous blood cell regeneration throughout life.
  • HSCs possess a unique capacity for self-renewal and controlled differentiation into various blood lineages.
  • Aging and developmental stages induce significant alterations in HSC properties and regulatory mechanisms.

Purpose of the Study:

  • To investigate the role of the Lin28b-let-7 pathway in regulating age-dependent changes in HSC function.
  • To explore the implications of these regulatory mechanisms for HSC-based therapies and leukemia development.

Main Methods:

  • Analysis of HSC populations and their differentiation potential.
  • Molecular profiling to assess Lin28b-let-7 pathway activity.
  • Comparative studies across different age groups and disease models.

Main Results:

  • The Lin28b-let-7 pathway acts as a key regulator of HSC self-renewal and differentiation.
  • Dysregulation of this pathway is linked to altered HSC behavior during aging.
  • The pathway's activity correlates with specific types of leukemia pathogenesis.

Conclusions:

  • The Lin28b-let-7 pathway is a critical determinant of HSC fate and function.
  • Understanding this pathway offers new avenues for improving HSC transplantation and gene therapy.
  • Targeting Lin28b-let-7 may provide insights into the distinct mechanisms of childhood and adult leukemias.