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Procedures which increase acute pain sensitivity also increase autotomy.

T J Coderre, R Melzack

    Experimental Neurology
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Rat paw self-mutilation after nerve injury is likely caused by pain or dysesthesia. Procedures that increase pain sensitivity also increased autotomy, supporting this sensory phenomenon hypothesis.

    Area of Science:

    • Neuroscience
    • Pain Research
    • Animal Models

    Background:

    • Peripheral nerve injury in rats often leads to autotomy (self-mutilation) of the denervated paw.
    • The underlying cause of autotomy, whether pain (hyperesthesia) or lack of sensation (anesthesia), remains unclear.

    Purpose of the Study:

    • To investigate whether autotomy following peripheral nerve transection is a pain-mediated phenomenon.
    • To determine if enhancing pain sensitivity increases the incidence or severity of autotomy.

    Main Methods:

    • Rats with sciatic and saphenous nerve transection were subjected to pain-sensitizing procedures.
    • Methods included prior heat injury, systemic administration of noradrenaline and pargyline, and intrathecal substance P injection.

    Main Results:

    Related Experiment Videos

    • All tested procedures significantly increased the level of autotomy in the rats.
    • This indicates a correlation between heightened pain sensitivity and autotomy behavior.

    Conclusions:

    • Autotomy following peripheral nerve injury is strongly suggested to be a result of a sensory phenomenon akin to pain or dysesthesia.
    • These findings provide evidence for a pain-based mechanism driving autotomy in this animal model.