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Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Updated: May 6, 2026

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

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Toxic equivalency factors for dioxin-like PCBs

U G Ahlborg¹, A Hanberg

¹Institute of Environmental Medicine, Karolinska Institutet, Box 210, S-171 77, Stockholm, Sweden.

Environmental Science and Pollution Research International

|November 16, 2013

Summary

No abstract available in PubMed .

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