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Updated: May 6, 2026

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Published on: November 6, 2013

Prion diseases.

Leonel T Takada¹, Michael D Geschwind

¹Cognitive and Behavioral Neurology Unit, Department of Neurology, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Seminars in Neurology

|November 16, 2013

Summary

This summary is machine-generated.

Prion diseases are rare, fatal neurodegenerative disorders caused by misfolded proteins. This review details sporadic, genetic, and acquired forms, including Jakob-Creutzfeldt disease, and their clinical and diagnostic features.

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Area of Science:

Neurology
Infectious Diseases
Protein Misfolding Diseases

Background:

Prion diseases are fatal neurodegenerative conditions.
Caused by infectious, misfolded proteins known as prions.
Classified into sporadic, genetic, and acquired forms.

Purpose of the Study:

To review the clinical features, diagnostic findings, and management of human prion diseases.
To provide a detailed overview of sporadic Jakob-Creutzfeldt disease (sJCD).
To discuss genetic and acquired prion disease classifications and prevention.

Main Methods:

Literature review of clinical features.
Analysis of neuroimaging and cerebrospinal fluid markers.
Review of neuropathological findings and PRNP gene mutations.

Main Results:

Sporadic JCD is the most common human prion disease.
Genetic prion diseases are linked to PRNP gene mutations.
Acquired prion diseases are decreasing due to increased awareness and prevention.

Conclusions:

Prion diseases present with diverse clinical and pathological features.
Accurate diagnosis relies on clinical, imaging, CSF, and pathological data.
Continued surveillance and prevention are crucial for acquired prion diseases.