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Related Experiment Video

Updated: May 6, 2026

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Genetically modified pigs to model human diseases.

Tatiana Flisikowska, Alexander Kind, Angelika Schnieke

    Journal of Applied Genetics
    |November 16, 2013
    PubMed
    Summary

    Genetically modified pigs offer a promising alternative to mice for studying human diseases. This review details porcine models for various conditions, advancing preclinical research and therapeutic development.

    Area of Science:

    • Biomedical research
    • Animal models
    • Genetics

    Background:

    • Genetically modified mice are valuable but limited for human disease research due to physiological differences.
    • Developing alternative animal models is crucial for advancing diagnostics and therapeutics.
    • Genetically modified pigs are emerging as a significant alternative.

    Purpose of the Study:

    • To provide a comprehensive review of genetically modified porcine models.
    • To highlight their potential for studying a wide range of human diseases.
    • To inform the development of new medical treatments and procedures.

    Main Methods:

    • Literature review of genetically modified porcine models.
    • Identification of diseases modeled in pigs.

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  • Analysis of the scope and application of these models.

    • Main Results:

    • Detailed review of genetically modified pig models for numerous diseases including cancers, cystic fibrosis, Duchenne muscular dystrophy, and neurodegenerative disorders.
    • Coverage of models for genetic disorders like hemophilia A and immunodeficiencies.
    • Inclusion of models for metabolic and cardiovascular diseases, Alzheimer's, and diabetes mellitus.

    Conclusions:

    • Genetically modified pigs represent a powerful preclinical research tool.
    • These models are essential for understanding disease mechanisms and developing novel therapies.
    • Porcine models offer significant advantages over traditional rodent models for certain human diseases.