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FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Related Experiment Video

Updated: May 6, 2026

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes
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Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

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FlyBase 102--advanced approaches to interrogating FlyBase.

Susan E St Pierre1, Laura Ponting, Raymund Stefancsik

  • 1The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA and Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.

Nucleic Acids Research
|November 16, 2013
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Summary
This summary is machine-generated.

FlyBase is a comprehensive database for Drosophila melanogaster research, offering advanced tools for gene function and genomic data exploration. It aids researchers in accessing and analyzing fruit fly biological information for various applications.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Developmental Biology

Background:

  • FlyBase is a primary resource for Drosophila melanogaster gene and genome information.
  • The fruit fly is a crucial model organism for biological research, including studies relevant to human disease.

Purpose of the Study:

  • To showcase advanced search systems and new tools within FlyBase.
  • To demonstrate how to effectively search for gene function and genomic data.

Main Methods:

  • Utilized TermLink for Controlled Vocabulary searches and RNA-Seq Search for gene expression analysis.
  • Employed BLAST server, GBrowse 2, and FeatureMapper for genomic data exploration.
  • Introduced QueryBuilder for complex database queries and programmatic data access.

Main Results:

  • Demonstrated advanced gene function searching using TermLink and RNA-Seq Search.
  • Highlighted new tools for genomic data retrieval, including FeatureMapper and an updated GBrowse 2.
  • Showcased QueryBuilder as a powerful tool for database interrogation.

Conclusions:

  • FlyBase provides robust and advanced tools for accessing and analyzing Drosophila melanogaster data.
  • The database facilitates research by enabling efficient exploration of gene function, expression, and genomic information.
  • New tools enhance the utility of FlyBase for diverse research needs, from basic biology to comparative genomics.