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The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases.

Sandra Orchard1, Mais Ammari, Bruno Aranda

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ 85721-0036, USA, Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 Rue Michel-Servet, CH-1211 Geneva 4, Switzerland, Department of Biology, University of Rome Tor Vergata, Rome 00133, Italy, Ontario Cancer Institute, the Campbell Family Institute for Cancer Research, and Techna Institute, University Health Network, Toronto, Ontario M5G 0A3, Canada, Cardiovascular Gene Annotation Initiative, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia V6T 1Z4 Canada, Mechanobiology Institute, National University of Singapore, T-Lab #05-01, 5A Engineering Drive 1, Singapore 117411, Singapore, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway, Research Institute IRCSS "Fondazione Santa Lucia", Rome 00179, Italy, Molecular Connections Pvt. Ltd., Bangalore 560 004, India, Institut de Biologie et Chimie des Protéines, Unité Mixte de Recherche 5086, Centre National de la Recherche Scientifique, Université Lyon 1, Lyon, France and Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

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The IntAct molecular interaction database now integrates MINT data, enhancing its curated literature and deposition resources. This merger streamlines curation efforts and expands the open-access molecular interaction data available.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Biochemistry

Background:

  • IntAct is a key open-source database for molecular interactions.
  • It supports data curation from literature and direct depositions.
  • A sophisticated web-based tool facilitates IMEx- and MIMIx-level curation.

Purpose of the Study:

  • To merge the MINT and IntAct databases.
  • To optimize resource utilization and maximize curation output.
  • To consolidate molecular interaction data within the IntAct platform.

Main Methods:

  • Manual curation of data from the literature.
  • Direct data depositions into the IntAct database.
  • Merging of manually curated data from MINT into IntAct.
  • Utilizing a sophisticated web-based curation tool.

Main Results:

  • All manually curated data from MINT has been transferred to IntAct.
  • The merged dataset is now available at EMBL-EBI.
  • IntAct continues to support multiple curation teams and quality control.

Conclusions:

  • The merger enhances the comprehensive nature of the IntAct molecular interaction database.
  • Consolidated data improves accessibility and research utility.
  • IntAct and MINT remain active contributors to the IMEx consortium.