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Related Experiment Video

Updated: May 5, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy.

Allyson Lipp¹, Gail Lusardi

¹Faculty of Health, Sport and Science, Department of Care Sciences, University of South Wales, Glyn Taff Campus, Pontypridd, Rhondda Cynon Taff, UK, CF37 1DL.

The Cochrane Database of Systematic Reviews

|November 16, 2013

Summary

This summary is machine-generated.

Prophylactic antibiotics significantly reduce peristomal infections in patients undergoing percutaneous endoscopic gastrostomy (PEG) tube placement. This meta-analysis of 13 RCTs confirms the benefit of systemic antimicrobial prophylaxis for PEG procedures.

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Published on: April 28, 2026

Area of Science:

Infectious Diseases
Gastroenterology
Surgical Oncology

Background:

Percutaneous endoscopic gastrostomy (PEG) is crucial for nutritional support but carries infection risks, especially with vulnerable patients and rising MRSA rates.
Patients undergoing PEG are often immunocompromised due to age, malnutrition, or underlying conditions like cancer, increasing susceptibility to infections.
The debate on antibiotic prophylaxis for PEG placement is influenced by the increasing incidence of methicillin-resistant Staphylococcus aureus (MRSA).

Purpose of the Study:

To determine if prophylactic systemic antimicrobials decrease peristomal infection risk following PEG tube placement.
To evaluate the efficacy of antimicrobial prophylaxis in preventing infections associated with PEG procedures.

Main Methods:

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted.
Searches included Cochrane Wounds Group Register, CENTRAL, Medline, Embase, and CINAHL up to August 2013.
Data extraction and quality assessment were performed independently by two reviewers; meta-analyses were conducted where appropriate.

Main Results:

A total of 13 eligible RCTs involving 1637 patients were included.
Pooled analysis of 12 trials demonstrated a statistically significant reduction in peristomal infection incidence with prophylactic antibiotics (OR 0.36, 95% CI 0.26 to 0.50).
One new trial comparing IV antibiotics with PEG-delivered antibiotics was identified but not included in the meta-analysis.

Conclusions:

Systemic prophylactic antibiotics are effective in reducing peristomal infections after PEG tube placement.
The findings support the routine use of antimicrobial prophylaxis to minimize infection risk in PEG procedures.