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Platyphylloside: Metabolism and digestibility reductionin vitro
K Sunnerheim-Sjöberg1, P G Knutsson
1Department of Chemistry, Uppsala University, Box 531, S-751 21, Uppsala, Sweden.
Journal of Chemical Ecology
|November 16, 2013
Summary
Platyphylloside metabolism in sheep reduces feed digestibility. Its breakdown product, centrolobol, is identified as the primary cause of this reduced digestibility, impacting animal nutrition.
Area of Science:
- Animal nutrition and metabolism
- Rumen microbiology
- Plant secondary metabolite degradation
Background:
- Platyphylloside, a plant glycoside, is known to decrease feed digestibility in ruminants.
- Understanding the metabolic pathways and active compounds responsible for this effect is crucial for improving livestock nutrition.
Purpose of the Study:
- To investigate the in vitro metabolism of platyphylloside in sheep rumen liquor.
- To identify the specific metabolites responsible for reducing feed digestibility.
Main Methods:
- Incubation of platyphylloside in sheep rumen liquor under in vitro conditions.
- Identification and quantification of metabolic intermediates and end products using analytical techniques.
Main Results:
- Platyphylloside was hydrolyzed to 5-hydroxy-3-platyphyllone, then reduced to 3-platyphyllone, and finally to centrolobol.
- A strong correlation was observed between the concentration of centrolobol and the reduced digestibility of the feed.
Conclusions:
- The metabolism of platyphylloside in the rumen leads to the formation of centrolobol.
- Centrolobol is the key metabolite responsible for the digestibility-reducing effects of platyphylloside in sheep, highlighting its importance in animal feed evaluation.
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