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Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
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Ventilator-associated pneumonia in an Italian pediatric intensive care unit: a prospective study

Maria Francesca Patria1, Giovanna Chidini, Ludovica Ughi

  • 1Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

World Journal of Pediatrics : WJP
|November 16, 2013
PubMed

Insights

Ventilator-associated pneumonia (VAP) affects 6.6% of pediatric intensive care unit patients, increasing hospital stay and mortality. Risk factors include re-intubation, tracheostomy, and enteral feeding.

Area of Science:

  • Pediatric critical care medicine
  • Infectious disease epidemiology
  • Mechanical ventilation

Background:

  • Ventilator-associated pneumonia (VAP) is a significant concern in pediatric intensive care units (PICUs).
  • Understanding VAP prevalence, risk factors, and outcomes is crucial for improving patient care.

Purpose of the Study:

  • To determine the prevalence of VAP in a European PICU.
  • To identify risk factors associated with VAP development.
  • To analyze the outcomes of VAP in mechanically ventilated children.

Main Methods:

  • Prospective study enrolling 451 children mechanically ventilated for ≥ 48 hours.
  • Data collected over a 3-year period in a European PICU.
  • Statistical analysis, including logistic regression, to identify risk factors.

Main Results:

  • VAP prevalence was 6.6% (30 children).
  • Children with VAP experienced significantly longer PICU and hospital stays (P<0.0001).
  • Independent risk factors for VAP included re-intubation (P=0.0001), tracheostomy (P=0.04), and enteral feeding (P=0.02).
  • VAP was associated with a higher mortality rate (P=0.04).

Conclusions:

  • A notable proportion of intubated children develop VAP, linked to invasive procedures.
  • VAP significantly increases healthcare costs and mortality.
  • Multicenter studies are essential to enhance VAP prevention and treatment strategies.
Abstract

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