Related Experiment Video
Updated: May 5, 2026
06:32
Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
Published on: May 2, 2025
930
[The usefulness of platelet function evaluation in clinical practice].
Ismail Elalamy1, Vasiliki Gkalea, Grigorios Gerotziafas
1Service d'hématologie biologique, Hôpital Tenon, AP-HP, Paris.
Annales De Biologie Clinique
|November 16, 2013
Summary
Platelet function tests, crucial for bleeding disorders, are expanding to cardiovascular disease and heparin-induced thrombocytopenia. Emerging data suggest these tests predict adverse events and aid diagnosis.
Area of Science:
- Hematology
- Clinical Pathology
- Cardiovascular Medicine
Context:
- Platelet function testing is vital for diagnosing bleeding disorders.
- Recent advancements enable broader applications in cardiovascular disease.
- New assays improve heparin-induced thrombocytopenia diagnosis.
Purpose:
- To review current methods for measuring platelet response.
- To discuss limitations and emerging data for platelet function studies.
- To highlight the clinical utility of platelet function testing.
Summary:
- Platelet function tests are essential for thrombosis and hemostasis regulation.
- Light transmission aggregometry and new devices expand clinical utility in cardiovascular disease.
- Functional assays offer easier diagnosis for heparin-induced thrombocytopenia.
Impact:
- Platelet function studies are becoming increasingly important in clinical practice.
- Ex vivo measurement of residual platelet response may predict adverse clinical events.
- This review supports the growing role of platelet function studies for clinicians and scientists.
Related Concept Videos
01:18Structure and Function of Platelets
7.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
7.2K
01:22Formation of the Platelet Plug
6.3K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.3K
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
1.6K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.6K