Pediatric perspective on pharmacogenomics
Adam Stevens1, Chiara De Leonibus, Daniel Hanson
1Institute of Human Development, Medical & Human Sciences, University of Manchester & Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, 5th Floor Research, Oxford Road, Manchester, M13 9WL, UK.
Pharmacogenomics
|November 19, 2013
Summary
Pharmacogenomics uses genetic information to tailor drug treatments. This review highlights its pediatric applications, considering developmental changes crucial for children
Area of Science:
- Genomic medicine
- Pediatric pharmacology
- Translational science
Background:
- High-throughput genomic technologies enhance understanding of disease and drug response.
- Pharmacogenomics identifies patients likely to respond to medications or experience adverse drug reactions.
- Most pharmacogenomic studies focus on adults, with limited research in pediatrics.
Purpose of the Study:
- To review pharmacogenomic research in pediatrics.
- To highlight the impact of developmental changes on pediatric drug response.
- To provide examples from common pediatric conditions.
Main Methods:
- Literature review of pharmacogenomic studies in pediatrics.
- Analysis of developmental factors influencing drug efficacy and toxicity in children.
- Case examples from common pediatric diseases.
Main Results:
- Pediatric pharmacogenomics is influenced by age-related developmental changes.
- Genetic variations impact drug response and toxicity differently in children versus adults.
- Pharmacogenomic data is crucial for optimizing pediatric drug therapy.
Conclusions:
- Pharmacogenomics offers personalized medicine approaches for pediatric patients.
- Understanding developmental context is essential for pediatric pharmacogenomic applications.
- Further research is needed to fully implement pharmacogenomics in pediatric care.
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