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Post-injection sciatic neuropathy in a cynomolgus macaque (Macaca fascicularis).
1Veterinary Services, Nonclinical Safety Assessment at Covance Laboratories, Inc., Chandler, Arizona, USA.
Journal of Medical Primatology
|November 19, 2013
Summary
Intramuscular injections in primates can cause traumatic injection neuropathy, leading to leg lameness and muscle atrophy. This condition was observed in a cynomolgus macaque following ketamine administration.
Area of Science:
- Veterinary Neurology
- Primate Medicine
- Toxicology
Background:
- Intramuscular injection is a common parenteral administration route in non-human primates.
- Proper injection technique is crucial to prevent iatrogenic injury.
Observation:
- A cynomolgus macaque presented with acute lameness and left hindlimb muscle atrophy.
- No external signs of trauma were evident on physical examination.
Findings:
- Ketamine administration via intramuscular injection was reported 12 days prior to presentation.
- Histologic examination confirmed traumatic injection neuropathy as the cause of clinical signs.
Implications:
- This case highlights the risk of peripheral nerve damage from intramuscular injections in primates.
- Veterinarians should consider injection site complications when diagnosing lameness in non-human primates.
- Careful technique and site selection are essential to mitigate risks associated with primate intramuscular injections.
