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Polysaccharides in Lentinus edodes: isolation, structure, immunomodulating activity and future prospective.

Xiaofei Xu¹, Huidan Yan, Jian Tang

¹a College of Light Industry and Food Sciences, South China University of Technology , 381 Wushan Road , Guangzhou , 510640 , China.

Critical Reviews in Food Science and Nutrition

|November 19, 2013

Summary

Lentinus edodes polysaccharides show potent antitumor and immunomodulating effects. This review details their extraction, structure, immune functions, and future potential.

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Area of Science:

* Medicinal Mushrooms and Natural Products Chemistry
* Immunology and Pharmacology

Background:

* Lentinus edodes (shiitake mushroom) is recognized for its nutritional and medicinal value.
* Polysaccharides are key bioactive compounds in Lentinus edodes, exhibiting significant antitumor and immunomodulatory properties.

Purpose of the Study:

* To comprehensively review the current understanding of Lentinus edodes polysaccharides.
* To cover extraction, purification, structural characteristics, and biological activities.

Main Methods:

* Literature review of scientific publications on Lentinus edodes polysaccharides.
* Analysis of studies detailing isolation techniques, structural elucidation, and immunological assays.

Main Results:

* Various polysaccharides have been isolated from Lentinus edodes using diverse methods.
* These polysaccharides demonstrate complex structures influencing their efficacy in modulating innate and adaptive immunity.
* Mechanisms of action involve enhancing immune cell activity and cytokine production.

Conclusions:

* Lentinus edodes polysaccharides are promising candidates for therapeutic applications due to their immune-enhancing and antitumor effects.
* Further research into structure-function relationships will optimize their use in medicine and health products.