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Modulating Ca2+ release by the IP3R/Ca2+ channel as a potential therapeutic treatment for neurological diseases

Carmen C M Chan1

  • 1Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, Wako, Saitama, Japan. chanccm@gmail.com.

Pharmaceutical Patent Analyst
|November 19, 2013
PubMed

Insights

New therapeutic strategies for neurodegenerative diseases focus on targeting inositol 1,4,5-trisphosphate receptors (IP3R). Patents explore peptides and IP3-limiting buffers to modulate IP3R activity for potential treatments.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Neurodegenerative disorders' pathogeneses are linked to inositol 1,4,5-trisphosphate receptors (IP3R).
  • Current understanding of these disorders' pathophysiologies and cures remains incomplete.
  • IP3R presents a potential convergence point for novel therapeutic interventions.

Purpose of the Study:

  • To review patents targeting the modulation of inositol 1,4,5-trisphosphate receptors (IP3R).
  • To explore novel therapeutic strategies for neurodegenerative diseases by targeting IP3R.

Main Methods:

  • Review of patents involving IP3R activity manipulation.
  • Analysis of therapeutic approaches utilizing peptides derived from IP3R-binding proteins.
  • Examination of methods employing buffers to limit IP3 availability.
  • Investigation of direct IP3R inhibition using chromophore-conjugated small molecules.

Main Results:

  • Patents generally involve peptides or IP3-limiting buffers to modulate IP3R activity.
  • One patent details direct, spatiotemporally specific IP3R inhibition via a synthetic molecule.
  • Most patented approaches are in early-stage research (in vitro or early in vivo).

Conclusions:

  • Modulating IP3R activity represents a promising avenue for neurodegenerative disease therapies.
  • Further research and development of these patented IP3R-targeting strategies are warranted.
  • Potential for more effective treatments for neurodegenerative diseases exists through IP3R manipulation.

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