Neural correlates of developmental coordination disorder.
Lieke H J Peters1, Carel G B Maathuis, Mijna Hadders-Algra
1Department of Paediatrics - Developmental Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Developmental Medicine and Child Neurology
|November 19, 2013
Summary
Neuroimaging studies reveal differences in brain activation and structure in children with developmental coordination disorder (DCD). Further research is needed to fully understand the neural basis of DCD and related motor impairments.
Area of Science:
- Neuroscience
- Developmental Pediatrics
- Radiology
Background:
- Developmental Coordination Disorder (DCD) affects motor skills in children.
- Neuroimaging data in DCD is limited, prompting a broader search including perinatal adversities and motor impairment.
Purpose of the Study:
- To systematically review neuroimaging studies in children with DCD.
- To explore neuroimaging findings in children with motor impairments secondary to perinatal adversities.
Main Methods:
- Conducted two systematic literature searches in PubMed, PsycINFO, and Web of Science.
- Included studies on neuroimaging in DCD and neuroimaging in children with perinatal adversities and motor impairment.
Main Results:
- Five DCD studies showed altered brain activation (fMRI) and internal capsule differences (DTI).
- Seven studies on perinatal adversities found associations between white matter abnormalities/MRI findings and motor impairment in some cases.
Conclusions:
- Neuroimaging data for DCD is scarce, but suggests involvement of multiple brain areas.
- Motor impairment in children with perinatal adversities is linked to white matter and MRI abnormalities.
- Hypothesize that some DCD cases may share neuropathophysiology with cerebral palsy; more research is required.
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