[In vitro activity of ceftaroline to MRSA isolates: a multicenter study]

Area of Science:

• Microbiology
• Infectious Diseases
• Pharmacology

Context:

• Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat due to limited treatment options.
• Ceftaroline, a broad-spectrum cephalosporin, is increasingly used for MRSA infections.
• Surveillance of antimicrobial resistance is crucial for effective treatment strategies.

Purpose:

• To evaluate the in vitro activity of ceftaroline against MRSA strains isolated from various clinical specimens across Turkey.
• To determine ceftaroline susceptibility profiles and minimum inhibitory concentration (MIC) values.
• To compare ceftaroline activity across different geographical regions and specimen types within Turkey.

Summary:

• A total of 192 MRSA isolates were tested for ceftaroline susceptibility using the broth microdilution method.
• 94.3% of isolates were susceptible (MIC ≤ 1 µg/mL), with MIC values ranging from 0.25-2 µg/mL.
• MIC50 and MIC90 values were 0.5 µg/mL and 1 µg/mL, respectively, showing consistent activity across Turkish centers.

Impact:

• Provides initial data on ceftaroline's efficacy against Turkish MRSA isolates.
• Suggests ceftaroline is a viable treatment option for MRSA infections in Turkey.
• Highlights the need for continued surveillance and large-scale studies on ceftaroline's effectiveness.