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Related Experiment Video

Updated: May 5, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Gemcitabine-induced thrombotic microangiopathy.

J Richmond1, P Gilbar, E Abro

  • 1Cancer and Palliative Care Services, Toowoomba Health Service, Toowoomba, Queensland, Australia.

Internal Medicine Journal
|November 19, 2013
PubMed
Summary

Thrombotic microangiopathy (TMA) is a serious condition affecting small blood vessels. This report details two cases where gemcitabine chemotherapy led to the development of TMA.

Keywords:
chemotherapygemcitabinethrombotic microangiopathy

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Area of Science:

  • Oncology
  • Hematology
  • Nephrology

Background:

  • Thrombotic microangiopathy (TMA) is a critical disorder involving platelet aggregation and end-organ damage.
  • While often idiopathic, certain drug classes, including cytotoxic chemotherapy, are implicated in TMA development.

Observation:

  • Gemcitabine, a widely used chemotherapy agent, has been increasingly associated with TMA.
  • This report presents two distinct patient cases experiencing TMA during gemcitabine treatment.

Findings:

  • The documented cases highlight a potential link between gemcitabine administration and the onset of TMA.
  • The incidence of gemcitabine-induced TMA may rise with its expanding clinical application.

Implications:

  • Awareness of gemcitabine-induced TMA is crucial for oncologists and hematologists.
  • Early recognition and management strategies are vital for patients undergoing gemcitabine chemotherapy to mitigate TMA risks.