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Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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The lectin ERGIC-53 goes viral.

Antonella Pasquato1, Stefan Kunz

  • 1Institute of Microbiology, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.

Cell Host & Microbe
|November 19, 2013
PubMed
Summary

Researchers found that the endoplasmic reticulum (ER)-Golgi intermediate compartment 53 kDa protein (ERGIC-53) binds to viral envelope glycoproteins. This interaction is essential for producing infectious viruses.

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Viral replication relies on the proper biosynthesis of fusion-competent envelope glycoproteins (GPs).
  • Understanding the cellular factors involved in this process is key to controlling viral infections.

Purpose of the Study:

  • To identify cellular proteins that interact with viral GPs.
  • To determine the role of these interactions in infectious virus production.

Main Methods:

  • Co-immunoprecipitation assays to identify binding partners.
  • Viral infectivity assays to assess the role of identified proteins.

Main Results:

  • The endoplasmic reticulum (ER)-Golgi intermediate compartment 53 kDa protein (ERGIC-53) was identified as a binding partner for viral GPs.

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  • ERGIC-53 is a crucial cellular factor required for the production of infectious viruses.

    • Conclusions:

    • ERGIC-53 plays a vital role in the viral life cycle by interacting with envelope glycoproteins.
    • Targeting the ERGIC-53-GP interaction could be a strategy for antiviral therapies.