Related Experiment Video
Updated: May 5, 2026

Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis): a multidisciplinary approach
1Consultant, former Head of Department, Clinic of Oral and Maxillofacial Surgery at Södersjukhuset, Stockholm, Sweden.
This study proposes a diagnostic and treatment model for undiagnosed inflammatory jaw conditions. Implementing a multidisciplinary approach significantly reduced the time from diagnosis to cure for chronic osteomyelitis patients.
Area of Science:
- Oral and Maxillofacial Surgery
- Rheumatology
- Dermatology
Background:
- Undiagnosed multiple inflammatory reactions present diagnostic challenges.
- Chronic osteomyelitis of the jaw requires a structured approach for effective management.
Purpose of the Study:
- To propose a model for the inquiry and treatment of patients with undiagnosed multiple inflammatory reactions.
- To improve diagnostic accuracy and treatment outcomes for chronic inflammatory jaw diseases.
Main Methods:
- Retrospective study of 43 patient records from an Oral and Maxillofacial Clinic.
- Diagnosis of primary chronic osteomyelitis (PCO) or secondary chronic osteomyelitis (SCO) based on symptoms and disease course.
Main Results:
- 85% of PCO patients met criteria for SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome.
- Diagnosis and treatment were lengthy and complex.
- Multidisciplinary treatment halved the time from diagnosis to cure.
Conclusions:
- A structured examination and treatment plan is proposed to enhance diagnostics and treatment for chronic inflammatory jaw diseases.
- Multidisciplinary care is crucial for improving patient outcomes.
Related Concept Videos
Staphylococcal Skin Infections
Acne Infection
Nephrotic Syndrome III : Nursing Management
Nephrotic Syndrome II : Assessment and Medical Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Peripheral Artery Disease III: Interprofessional Care