Related Experiment Video

Updated: May 5, 2026

Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood
09:29

Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood

Published on: February 1, 2013

19.7K

Acquired aplastic anemia in children

Helge D Hartung1, Timothy S Olson, Monica Bessler

  • 1Division of Hematology, Department of Pediatrics, Comprehensive Bone Marrow Failure Center, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, ARC 302, Philadelphia, PA 19104, USA.

Pediatric Clinics of North America
|November 19, 2013
PubMed

Insights

This review covers acquired aplastic anemia in children, detailing its causes, diagnosis, and treatment options like bone marrow transplantation and immunosuppressive therapy for better clinical understanding and management.

Area of Science:

  • Pediatric Hematology
  • Oncology
  • Immunology

Background:

  • Acquired aplastic anemia is a rare but severe pediatric disorder.
  • It is characterized by bone marrow failure.
  • Prompt diagnosis and management are crucial.

Purpose of the Study:

  • To provide a concise, practice-based review of acquired aplastic anemia in children.
  • To enhance clinician understanding of the disease etiology, diagnosis, and management.
  • To offer guidelines for managing this serious pediatric condition.

Main Methods:

  • Review of current literature on acquired aplastic anemia.
  • Detailed discussion of established and emerging treatment modalities.
  • Synthesis of diagnostic criteria and management protocols.

Main Results:

  • Comprehensive overview of the etiology and diagnostic approaches.
  • In-depth analysis of bone marrow transplantation, immunosuppressive therapy, and supportive care.
  • Emphasis on the multidisciplinary approach to patient management.

Conclusions:

  • Effective management requires a thorough understanding of the disease.
  • Treatment strategies should be tailored to individual patient needs.
  • Continued research is essential to improve outcomes for children with acquired aplastic anemia.

Keywords:
Acquired aplastic anemiaBone marrow failureBone marrow transplant for severe aplastic anemia in childrenImmune-mediated aplastic anemiaImmunosuppressive therapy for severe aplastic anemia in children

More Related Videos

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

8.7K
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.1K

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.8K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.1K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.7K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
975
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K