Antihypertensive therapy with indoramin in the elderly

Area of Science:

• Cardiology
• Geriatrics
• Pharmacology

Background:

• Hypertension is a prevalent condition in elderly individuals.
• Effective and safe antihypertensive treatments are crucial for this demographic.

Purpose of the Study:

• To evaluate the antihypertensive efficacy and safety of indoramin in elderly patients.
• To compare indoramin monotherapy with combination therapy including a thiazide diuretic.

Main Methods:

• A study involving 215 elderly patients (≥60 years) with hypertension.
• Patients received either indoramin alone or in combination with a thiazide diuretic.
• Blood pressure was monitored, and treatment outcomes were assessed over at least 6 months.

Main Results:

• Both treatment regimens significantly reduced supine blood pressure (p < 0.001).
• Satisfactory blood pressure reduction was achieved in 69% (indoramin alone) and 75% (indoramin + diuretic) of patients.
• Indoramin was well-tolerated, with only 7% discontinuing due to adverse effects like drowsiness, fatigue, and dizziness.

Conclusions:

• Indoramin, alone or with a thiazide diuretic, is a safe and effective antihypertensive treatment for elderly patients.
• The combination therapy required a lower mean daily indoramin dosage compared to monotherapy.
• Indoramin offers a well-tolerated option for managing hypertension in the elderly.