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Updated: May 5, 2026

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Published on: January 27, 2019
Probiotics for infantile colic: a systematic review.
Jasim Anabrees1, Flavia Indrio, Bosco Paes
1Neonatal Care, Sulaiman Al Habib Medical Group, Arrayan Hospital, P,O, Box 272069, Riyadh, 11352, Saudi Arabia. jasim1800@yahoo.com.
Probiotic supplementation with Lactobacillus reuteri significantly reduced crying time in breastfed infants with colic. Further research is needed for formula-fed infants and definitive conclusions.
Area of Science:
- Pediatrics
- Microbiology
- Gastroenterology
Background:
- Infantile colic is a common condition causing parental distress.
- Altered gut microbiota, including reduced Lactobacillus and increased coliforms, may contribute to colic.
- Probiotic supplementation is being investigated as a treatment for infantile colic.
Purpose of the Study:
- To systematically review the efficacy of probiotic supplementation in reducing crying time.
- To evaluate the success rate of probiotic treatment for infantile colic.
Main Methods:
- Searched MEDLINE, EMBASE, and Cochrane Central Register for randomized controlled trials.
- Included term, healthy infants diagnosed with colic.
- Performed a meta-analysis using Cochrane Collaboration methodology.
Main Results:
- Three trials with 209 breastfed infants were analyzed.
- Lactobacillus reuteri supplementation significantly reduced crying time by a mean difference of -56.03 minutes.
- Probiotics significantly increased treatment success (RR 0.06) with a number needed to treat of 2.
Conclusions:
- Lactobacillus reuteri shows potential for treating colic-related crying in exclusively breastfed infants.
- Evidence for probiotic efficacy in formula-fed infants with colic remains inconclusive.
- Larger, rigorously designed studies are needed for definitive conclusions.
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