Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A very handy spine!

European annals of otorhinolaryngology, head and neck diseases·2024
Same author

MRI underestimates presence and size of knee osteophytes using CT as a reference standard.

Osteoarthritis and cartilage·2023
Same author

Somatic mutational landscape of extracranial arteriovenous malformations and phenotypic correlations.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

[Phaeochromocytoma and paraganglioma].

La Revue de medecine interne·2019
Same author

Abstracts of the 40th National Congress of Medicine Tunis, 19-20 October 2017.

La Tunisie medicale·2018
Same author

Reirradiation with concurrent bevacizumab for recurrent high-grade gliomas in adult patients.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2017
Same journal

Assessment of morbidity and mortality in emergency tracheotomy in head-and-neck cancer patients under palliative care.

European annals of otorhinolaryngology, head and neck diseases·2026
Same journal

Necrotizing toxic laryngitis following combined polysubstance smoking of crack cocaine and heroin.

European annals of otorhinolaryngology, head and neck diseases·2026
Same journal

French-language adaptation and linguistic validation of the ETDQ-7 Eustachian tube dysfunction assessment questionnaire following COSMIN guidelines.

European annals of otorhinolaryngology, head and neck diseases·2026
Same journal

Prognostic impact of invasion patterns and circumferential spread of internal carotid artery on survival in patients with nasopharyngeal carcinoma.

European annals of otorhinolaryngology, head and neck diseases·2026
Same journal

Palatine tonsil metastasis from small cell lung cancer.

European annals of otorhinolaryngology, head and neck diseases·2026
Same journal

Impact of great auricular nerve preservation status post parotidectomy on quality of life.

European annals of otorhinolaryngology, head and neck diseases·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

10.2K

Malignant head/neck paragangliomas. Comparative study.

A Mediouni1, S Ammari1, M Wassef2

  • 1Service de médecine nucléaire, hôpital Lariboisière (Assistance Publique-Hôpitaux de Paris), 2, rue Ambroise-Paré, 75010 Paris, France.

European Annals of Otorhinolaryngology, Head and Neck Diseases
|November 19, 2013
PubMed
Summary
This summary is machine-generated.

Malignant head and neck paragangliomas are rare, often occurring in younger patients with multifocal or secreting tumors, and are linked to SDH-B mutations. Further investigation with imaging is recommended for high-risk individuals.

Keywords:
(18)FDG-PETMalignant head and neck paragangliomaMetastasesOctreoscanSDHx mutation

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

18.5K

Related Experiment Videos

Last Updated: May 5, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

10.2K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

18.5K

Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Paragangliomas are rare neuroendocrine tumors arising from neural crest cells.
  • Head and neck paragangliomas can be benign or malignant, with distinct clinical and genetic features.
  • Distinguishing malignant from benign paragangliomas is crucial for appropriate management.

Purpose of the Study:

  • To report 11 cases of malignant head and neck paraganglioma.
  • To compare malignant and benign head and neck paragangliomas regarding epidemiology, clinical presentation, genetics, natural history, and treatment.
  • To identify risk factors and optimal diagnostic strategies for malignant paragangliomas.

Main Methods:

  • Retrospective analysis of 142 patients with head and neck paraganglioma (2001-2008).
  • Data collected included age, gender, tumor site, multifocality, secretory function, imaging findings (CT, MRI, Octreoscan, 18F-FDG PET), and genetic test results.
  • Comparison between 11 malignant and 131 benign cases.

Main Results:

  • Malignant paragangliomas (7.7%) were diagnosed at a younger mean age (38 vs. 45 years) and predominantly occurred in males.
  • Malignant cases showed a higher prevalence of carotid body tumors, secreting tumors (27% vs. 5%), and multifocal tumors (46% vs. 20%).
  • Metastases commonly involved bone and lymph nodes; tympanic paragangliomas were not malignant in this series.

Conclusions:

  • Malignant head and neck paragangliomas are associated with younger age, multifocal disease, carotid location, and SDH-B mutations.
  • Whole-body scintigraphy and spine MRI are recommended for high-risk patients.
  • Despite malignancy, the slow disease progression may allow for a favorable short-term prognosis.