Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cluster Sampling Method01:20

Cluster Sampling Method

11.1K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
11.1K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

2.5K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
2.5K
The Mitotic Spindle02:27

The Mitotic Spindle

7.1K
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
7.1K
The Mitotic Spindle02:27

The Mitotic Spindle

4.9K
4.9K
Subatomic Particles03:37

Subatomic Particles

92.9K
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
92.9K
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

7.1K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chaperone overexpression boosts heterologous small molecule production in Saccharomyces cerevisiae.

Microbial cell factories·2025
Same author

Comparative genomics of <i>Aspergillus nidulans</i> and section <i>Nidulantes</i>.

Current research in microbial sciences·2025
Same author

Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii.

FEMS yeast research·2024
Same author

Genomic Analysis of <i>Aspergillus</i> Section <i>Terrei</i> Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation.

Journal of fungi (Basel, Switzerland)·2024
Same author

Genome-wide host-pathway interactions affecting cis-cis-muconic acid production in yeast.

Metabolic engineering·2024
Same author

CRI-SPA: a high-throughput method for systematic genetic editing of yeast libraries.

Nucleic acids research·2023

Related Experiment Video

Updated: May 5, 2026

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'
10:31

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

10.5K

Supercluster takes a walk on the wild side.

Jakob B Nielsen1, Mikael R Andersen, Uffe H Mortensen

  • 1Department of Systems Biology, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark.

Trends in Microbiology
|November 19, 2013
PubMed
Summary

Researchers genetically dissected a gene supercluster in Aspergillus fumigatus, revealing layered gene regulation and intertwined gene clusters for secondary metabolite production.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Aspergillus fumigatus is an opportunistic fungal pathogen.
  • Secondary metabolites play crucial roles in fungal biology and pathogenesis.
  • Understanding the genetic regulation of secondary metabolite production is essential.

Purpose of the Study:

  • To genetically dissect the gene supercluster responsible for secondary metabolite production in Aspergillus fumigatus.
  • To elucidate the regulatory mechanisms governing the expression of these genes.

Main Methods:

  • Genetic analysis of the gene supercluster.
  • Gene expression profiling.
  • Bioinformatic analysis of gene clusters.

Main Results:

More Related Videos

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.0K
Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry
12:11

Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry

Published on: April 8, 2020

9.2K

Related Experiment Videos

Last Updated: May 5, 2026

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'
10:31

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

10.5K
Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.0K
Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry
12:11

Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry

Published on: April 8, 2020

9.2K
  • The study identified a complex gene supercluster involved in secondary metabolite biosynthesis.
  • Gene regulation occurs at multiple hierarchical levels.
  • Genes within specific clusters are found to be interconnected and interdependent.

Conclusions:

  • The genetic architecture of secondary metabolite production in Aspergillus fumigatus is highly complex.
  • Layered regulatory mechanisms ensure coordinated gene expression.
  • Intertwined gene clusters suggest co-evolution and functional linkage.