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Bioactive compounds from Stuhlmannia moavi from the Madagascar dry forest
Yixi Liu1, Liva Harinantenaina, Peggy J Brodie
1Department of Chemistry and the Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, USA.
Bioorganic & Medicinal Chemistry
|November 19, 2013
Summary
The Madagascar plant Stuhlmannia moavi yielded a potent naphthoquinone, stuhlmoavin, showing significant antiproliferative activity against ovarian cancer cells. This compound also exhibited weak antimalarial properties.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Stuhlmannia moavi, a Madagascar plant, is recognized for its potential medicinal properties.
- Natural products are a vital source for discovering novel therapeutic agents.
Purpose of the Study:
- To isolate and characterize bioactive compounds from Stuhlmannia moavi extracts.
- To evaluate the antiproliferative and antimalarial activities of isolated compounds.
Main Methods:
- Bioassay-directed fractionation of plant extracts.
- Structure elucidation using Nuclear Magnetic Resonance (NMR) and mass spectrometry.
- Single crystal X-ray analysis for structural confirmation.
- In vitro assays to determine IC50 values against human ovarian cancer and Plasmodium falciparum.
Main Results:
- Stuhlmoavin (1), a novel naphthoquinone, was identified as the most active compound with an IC50 of 8.1 μM against A2780 ovarian cancer cells.
- Known compounds bonducellin (2) and several stilbenoids (3-7) were also isolated.
- Compounds 1-3 demonstrated weak antimalarial activity against Plasmodium falciparum (IC50 values 23-27 μM).
Conclusions:
- Stuhlmoavin is a promising antiproliferative agent against ovarian cancer.
- Stuhlmannia moavi is a valuable source of bioactive natural products with potential therapeutic applications.
Keywords:
1,4-NaphthoquinoneANNNBEZJTNCXHY-NSCUHMNNSA-NAOMAYOSPRMTXRK-NSCUHMNNSA-NAntimalarial activityAntiproliferative activityCDRPUGZCRXZLFL-OWOJBTEDSA-NDLQSYZMPSWHYMW-XYOKQWHBSA-NHomoisoflavonoidLeguminosaePHMHDRYYFAYWEG-NSCUHMNNSA-NPHRQNTXVBVJWJE-UHFFFAOYSA-NQNVSXXGDAPORNA-SNAWJCMRSA-NX-ray crystallography
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