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Real-time Digital Imaging of Leukocyte-endothelial Interaction in Ischemia-reperfusion Injury (IRI) of the Rat Cremaster Muscle
15:07

Real-time Digital Imaging of Leukocyte-endothelial Interaction in Ischemia-reperfusion Injury (IRI) of the Rat Cremaster Muscle

Published on: August 5, 2012

Rheological importance of acute-phase reactants

J Stuart

    Nouvelle Revue Francaise D'Hematologie
    |January 1, 1986
    PubMed

    Acute vascular events, and also chronic atherosclerotic vascular disease, are associated with a rise in blood level of several acute-phase reactants. Of these, fibrinogen is of particular rheological importance since hyperfibrinogenaemia causes hyperviscosity of plasma and whole blood and is an adverse prognostic factor in intermittent claudication, coronary artery disease, and stroke. Activation of the monocyte-macrophage system by fibrinogen degradation products, with release of interleukin-1 and secondary stimulation of liver and bone marrow, may be of pathogenic importance in the stress responses of acute and chronic vascular disease.

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