Towards the realisation of lead-oriented synthesis

Richard Doveston1, Stephen Marsden2, Adam Nelson1

  • 1School of Chemistry, University of Leeds, Leeds LS2 9JT, UK; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

Drug Discovery Today
|November 19, 2013
PubMed
Summary

Developing diverse, lead-like molecules for drug discovery is difficult. Lead-oriented synthesis strategies and new reactions for polar substrates are needed to create varied molecular scaffolds effectively.

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