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Updated: May 5, 2026

Combining Solid-state and Solution-based Techniques: Synthesis and Reactivity of ChalcogenidoplumbatesII or IV
Published on: December 29, 2016
Towards the realisation of lead-oriented synthesis
Richard Doveston1, Stephen Marsden2, Adam Nelson1
1School of Chemistry, University of Leeds, Leeds LS2 9JT, UK; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.
Developing diverse, lead-like molecules for drug discovery is difficult. Lead-oriented synthesis strategies and new reactions for polar substrates are needed to create varied molecular scaffolds effectively.
Area of Science:
- Medicinal Chemistry
- Synthetic Organic Chemistry
Background:
- Sourcing diverse lead-like molecules for drug discovery is a significant challenge.
- Lead-oriented synthesis (LOS) aims to prepare compounds with desirable drug-like properties.
Purpose of the Study:
- To describe methods for preparing lead-like molecular scaffolds.
- To present these methods within diversity-oriented synthetic strategies.
Main Methods:
- Exploration of synthetic strategies for generating molecular diversity.
- Focus on methods applicable to lead-like chemical space.
Main Results:
- Identification of current challenges in sourcing lead-like molecules.
- Discussion of potential synthetic approaches for scaffold variation.
Conclusions:
- Development of a broader reaction toolkit is necessary.
- Reactions must be reliable with more polar substrates for improved scaffold combination.
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