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Antidepressant-induced sexual dysfunction in men.

Robert Taylor Segraves1, Richard Balon2

  • 1Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Pharmacology, Biochemistry, and Behavior
|November 19, 2013
PubMed
Summary
This summary is machine-generated.

Antidepressant drugs, particularly those affecting serotonin, frequently cause sexual dysfunction in men, especially ejaculatory delay. Medications targeting adrenergic or dopaminergic systems show a lower incidence of these side effects.

Keywords:
AntidepressantSerotoninSexual disorderSexual dysfunctionSide effect

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Sexual Medicine

Background:

  • Antidepressant medications are widely prescribed for mood disorders.
  • Sexual dysfunction is a common and often distressing side effect of many antidepressants.
  • Existing literature suggests a link between antidepressant use and sexual dysfunction in both men and women.

Purpose of the Study:

  • To review the available evidence on the incidence of treatment-emergent sexual dysfunction in men receiving antidepressant therapy.
  • To compare the rates of sexual dysfunction associated with different classes of antidepressant medications.

Main Methods:

  • Systematic review of double-blind controlled trials and large clinical series.
  • Analysis of reported sexual dysfunction incidence in men treated with various antidepressant drug classes.

Main Results:

  • Serotonergic antidepressants (SSRIs, SNRIs) are associated with a high incidence of sexual dysfunction, particularly ejaculatory delay.
  • Antidepressant drugs primarily acting on adrenergic or dopaminergic systems demonstrate a significantly lower incidence of sexual dysfunction in men.

Conclusions:

  • The choice of antidepressant medication can influence the risk of developing sexual dysfunction in men.
  • Clinicians should consider the potential for sexual side effects when prescribing antidepressants, especially serotonergic agents.