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Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
Ihsan Sami Uyar1, Suleyman Onal, M Besir Akpinar
1Department of Cardiothoracic Surgery, Faculty of Medicine, Şifa University, Izmir, Turkey.
Cardiovascular Journal of Africa
|November 19, 2013
Summary
Alpha-lipoic acid (LA) may reduce inflammation during cardiac surgery. This study found LA significantly decreased pro-inflammatory cytokine levels, IL-6 and IL-8, in patients undergoing coronary artery bypass grafting.
Area of Science:
- Cardiology
- Immunology
- Biochemistry
Background:
- Cardiopulmonary surgery using extracorporeal circulation (ECC) can trigger pro-inflammatory responses.
- Alpha-lipoic acid (LA) possesses antioxidant properties suggested by its biochemical pathways.
Purpose of the Study:
- To evaluate the effect of alpha-lipoic acid (LA) on inflammatory markers in patients undergoing coronary artery bypass graft (CABG) operations.
- To assess the potential of LA as an anti-inflammatory agent during cardiac surgery.
Main Methods:
- Patients with coronary heart disease scheduled for CABG were divided into control and LA treatment groups.
- Blood samples were collected pre-operatively and at 48 hours post-administration of LA.
- Levels of interleukin-6 (IL-6), interleukin-8 (IL-8), complement C3 and C4, C-reactive protein (CRP), and haptoglobin were measured.
Main Results:
- Post-surgery, IL-6 and IL-8 levels were significantly elevated.
- LA treatment significantly reduced IL-6 and IL-8 levels in a time-dependent manner compared to controls.
- LA administration also decreased elevated C3 and C4 levels observed after surgery.
Conclusions:
- Alpha-lipoic acid (LA) demonstrates potential benefits in mitigating the inflammatory response during cardiac surgery.
- LA may be a useful therapeutic agent to reduce cytokine release and associated oxidative damage in patients undergoing CABG.
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