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Large-scale cell culture in biotechnology.

W R Arathoon, J R Birch

    Science (New York, N.Y.)
    |June 13, 1986
    PubMed
    Summary

    This review covers large-scale cell culture applications, challenges, and future potential, focusing on mammalian cells. It highlights established commercial processes and emerging innovations in the field.

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    Bioprocess technology·1990

    Area of Science:

    • Biotechnology
    • Cell Biology
    • Bioprocessing

    Background:

    • Large-scale cell culture is crucial for producing biologics and pharmaceuticals.
    • Commercial processes are often proprietary, limiting detailed public data.
    • Mammalian cell culture dominates industrial applications.

    Purpose of the Study:

    • To review the current status of large-scale cell culture.
    • To discuss its diverse applications, inherent problems, and future potential.
    • To provide an overview of both established and innovative cell culture technologies.

    Main Methods:

    • Literature review of commercial and research publications.
    • Analysis of established large-scale cell culture processes.
    • Exploration of recent innovations and their potential impact.

    Main Results:

    • Commercial large-scale cell culture primarily utilizes mammalian cells.
    • Key challenges include process scalability, cost-effectiveness, and regulatory compliance.
    • Emerging innovations show promise for enhanced efficiency and novel applications.

    Conclusions:

    • Large-scale cell culture remains a vital area in biotechnology.
    • Addressing current challenges is key to unlocking future potential.
    • Continued innovation is expected to drive advancements in cell-based manufacturing.

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