[Gas exchange, microcirculation and blood kinins in patients with chronic nonspecific lung diseases]

The state of gas exchange, microcirculation (MC) and blood kinin was examined in 212 patients with chronic non-specific pulmonary diseases (197 with respiratory insufficiency, 15 without it). Noticeable activation of blood kinins with a rise of kallikrein, a decrease in alpha 2-macroglobulin and kinase activity were revealed in patients with respiratory insufficiency (RI), degree I and II, expressed in MC disorder with perivascular and intravascular changes. Kininogesis suppression with a decrease in all indices was noted in patients with RI, degree III, with progressive hypoxemia, hypercapnia, MC disorder in all the links. An insignificant positive time course in the state of gas exchange, MC and blood kinins after therapy was indicative of insufficient efficacy of multiple modality therapy and permitted recommendation of drugs correcting disorders in the above systems.