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Outliers on the dose-response curve: if the problem is not concentration, then what?

Sheldon H Preskorn1

  • 1SHELDON H. PRESKORN, MD, is Professor, Department of Psychiatry, University of Kansas School of Medicine-Wichita; Chief Science Officer and Medical Director, Kansas University-Wichita Clinical Trials Unit (KU-W CTU), Wichita, Kansas; and research psychiatrist, Laureate Institute for Brain Research, Tulsa, Oklahoma. He has more than 35 years of drug development research experience at all levels (i.e., preclinical through Phase IV) and has been a principal investigator on over 350 clinical trials-funded by industry, the federal government, or private foundations-including trials of every antidepressant and antipsychotic medication marketed in the United States over a period of 25 years. Dr. Preskorn maintains a website at http://www.preskorn.com where readers can access previous columns and other publications.

Journal of Psychiatric Practice
|November 19, 2013
PubMed

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