Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid hormones in generalized scleroderma. A controlled study.

J Serup, H Hangdrup

    Acta Dermato-Venereologica
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sequels to tattoo removal by caustic products.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2018
    Same author

    MR scanning, tattoo inks, and risk of thermal burn: An experimental study of iron oxide and organic pigments: Effect on temperature and magnetic behavior referenced to chemical analysis.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2017
    Same author

    Tattoo removal by Q-switched yttrium aluminium garnet laser: client satisfaction.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2017
    Same author

    Site, gender and age variation in normal skin colour on the back and the forearm: tristimulus colorimeter measurements.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2016
    Same author

    The 20-year Anniversary of the International Society for Bioengineering and the Skin (ISBS).

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2016
    Same author

    Retirement of Klaus Hoffmann as ISSI President.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2016
    Same journal

    A Facial Lesion with Cord-like Induration and Ring-like Appearance on MRI: A Quiz.

    Acta dermato-venereologica·2026
    Same journal

    Real-world Outcomes of Adalimumab in Hidradenitis Suppurativa: A 10-year Retrospective Longitudinal Study.

    Acta dermato-venereologica·2026
    Same journal

    An 8-year-old Girl with Multiple Whitish Dots on the Hair Shaft: A Quiz.

    Acta dermato-venereologica·2026
    Same journal

    A Congenital Subcutaneous Tumour of the Scalp in a Child: A Quiz.

    Acta dermato-venereologica·2026
    Same journal

    Commentary on: "The Effects of Sun Exposure and Pigmentation Phenotype on Prognosis in Metastatic Melanoma".

    Acta dermato-venereologica·2026
    Same journal

    Treatment Response to JAK Inhibitors in Long-standing Alopecia Areata (≥8 Years): A Real-world Observational Study.

    Acta dermato-venereologica·2026
    See all related articles

    Generalized scleroderma is associated with mild myxedema, indicated by altered thyroid hormone levels. This suggests a subtle, subclinical thyroid issue in scleroderma patients.

    Area of Science:

    • Endocrinology
    • Rheumatology
    • Internal Medicine

    Background:

    • Generalized scleroderma is an autoimmune disease affecting connective tissues.
    • Thyroid dysfunction can occur in autoimmune conditions, but its association with scleroderma requires further clarification.

    Purpose of the Study:

    • To investigate thyroid metabolism parameters in patients with generalized scleroderma.
    • To determine the prevalence and nature of thyroid dysfunction in scleroderma.

    Main Methods:

    • Analysis of thyroid metabolism parameters in 42 patients with generalized scleroderma and age/sex-matched healthy controls.
    • Measurement of free thyroxine, free triiodothyronine, total thyroxine, total triiodothyronine, reverse triiodothyronine, and thyroid-stimulating hormone levels.

    Related Experiment Videos

    Main Results:

    • Patients with scleroderma showed decreased free thyroxine and free triiodothyronine, and increased thyroid-stimulating hormone, indicating mild myxedema.
    • Total thyroxine levels were normal, while total triiodothyronine was elevated, possibly due to abnormal serum protein binding.
    • Normal reverse triiodothyronine and thyroid-stimulating immunoglobulin levels suggested preserved peripheral metabolism and no autoimmune thyroid stimulation.

    Conclusions:

    • A mild myxedema state is associated with generalized scleroderma.
    • The findings suggest a slight, subclinical thyroid affection in scleroderma patients.