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Palmoplantar eruption associated with etretinate therapy
Acta Dermato-Venereologica
|January 1, 1986
Summary
Psoriatic patients experienced unusual papular lesions on palms and soles during etretinate treatment. These lesions resolved spontaneously without dose adjustment, suggesting a transient adverse reaction to etretinate.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Etretinate is a retinoid medication used for psoriasis treatment.
Purpose of the Study:
- To report an unusual adverse reaction to etretinate therapy.
Main Methods:
- Observational case series of five psoriatic patients.
- Clinical observation of skin lesions.
- Histological examination in two cases.
Main Results:
- Five patients developed papular lesions on palms and soles after starting etretinate.
- Histology was non-specific.
- Lesions resolved spontaneously without dose modification.
Conclusions:
- Transient papular lesions on palms and soles may be an unreported adverse effect of etretinate.
- The rapid onset and resolution might explain the lack of previous reports.