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Overexpression of Bcl-3 inhibits the development of marginal zone B cells

Nadine Hövelmeyer1, Marcus A Wörns, Sonja Reissig

  • 1Institute for Molecular Medicine, Johannes Gutenberg-University of Mainz, Mainz, Germany.

European Journal of Immunology
|November 19, 2013
PubMed

The transcription factor Bcl-3 functions as a proto-oncogene via regulation of cell proliferation and apoptosis. Bcl-3 is an atypical member of the IκB family and plays a central role in the immune response through interactions with the NF-κB subunits p50 and p52. To investigate the impact of Bcl-3 on B-cell maturation and regulation, we generated mice that overexpress Bcl-3 specifically in B cells. Interestingly, these mice lack marginal zone B cells and exhibit a significant reduction in the number of B-1 B cells. Further, B cells from these mice are impaired in their proliferative capacity. Our data demonstrate that the overexpression of the transcription factor Bcl-3 inhibits germinal center formation, marginal zone B-cell development, and affects the B-1 B-cell compartment.

Keywords:
B-1 B cellsBcl-3Marginal zone B cellNF-κB

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