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Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
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Efficacy of metabolic surgery on HbA1c decrease in type 2 diabetes mellitus patients with BMI <35 kg/m2--a review
Kee Yuan Ngiam1, Wei-Jei Lee, Yi-Chih Lee
1Department of Surgery, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828.
Obesity Surgery
|November 19, 2013
Summary
Metabolic surgery effectively lowers glycated hemoglobin A1c (HbA1c) in type 2 diabetes mellitus (T2DM) patients with a BMI under 35. This intervention significantly reduces HbA1c, indicating improved diabetes control.
Area of Science:
- Metabolic Surgery
- Endocrinology
- Bariatric Surgery
Background:
- Elevated glycated hemoglobin A1c (HbA1c) is a key risk factor for type 2 diabetes mellitus (T2DM) complications.
- Patients with T2DM and a body mass index (BMI) below 35 kg/m(2) often require effective interventions to manage HbA1c levels.
Purpose of the Study:
- To review the efficacy of various metabolic surgeries in reducing HbA1c in T2DM patients with BMI <35 kg/m(2).
- To assess the impact of metabolic surgery on glycemic control and BMI in this specific patient population.
Main Methods:
- An electronic literature search was conducted on MEDLINE for studies published between 1987 and 2013.
- Keywords included 'metabolic surgery', 'type 2 diabetes mellitus', and 'BMI <35 kg/m(2)'.
- Data from 53 articles involving 2,258 patients were analyzed.
Main Results:
- Metabolic surgery resulted in a weighted mean HbA1c reduction of -2.8% (p < 0.01) and a mean BMI decrease of -5.5 kg/m(2) (p < 0.01).
- A significant correlation was observed between the percentage change in HbA1c and BMI.
- Adjustable gastric banding and duodenal jejunal bypass showed less efficacy compared to other procedures in reducing BMI and HbA1c.
Conclusions:
- Metabolic surgery is a highly effective treatment for decreasing HbA1c in T2DM patients with a BMI <35 kg/m(2).
- The degree of HbA1c reduction can serve as a valuable indicator of diabetes mellitus control following metabolic surgery.
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