Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.9K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.9K
Cell Migration01:09

Cell Migration

16.6K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
16.6K
Cell Migration01:19

Cell Migration

6.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.1K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.8K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.8K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

5.0K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
5.0K
Neurons: The Axon01:21

Neurons: The Axon

13.6K
Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment....
13.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration.

The Journal of clinical investigation·2026
Same author

Embryonic MGE Precursor Cells Grafted into Adult Rat Striatum Integrate and Ameliorate Motor Symptoms in 6-OHDA-Lesioned Rats.

Cell stem cell·2026
Same author

Single-cell proteomic landscape of the developing human brain.

Nature biotechnology·2026
Same author

The need for a global effort to attend to human neural organoid and assembloid research.

Science (New York, N.Y.)·2025
Same author

The new frontier in understanding human and mammalian brain development.

Nature·2025
Same author

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation.

Neuron·2025

Related Experiment Video

Updated: May 5, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

12.8K

The dynamics of neuronal migration.

Qian Wu1, Jing Liu, Ai Fang

  • 1Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China.

Advances in Experimental Medicine and Biology
|November 19, 2013
PubMed
Summary

Neuronal migration is crucial for brain development and proper cortical lamination. Disruptions in this process can lead to severe neurological disorders, highlighting the importance of understanding its molecular mechanisms.

More Related Videos

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

9.7K
Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

14.5K

Related Experiment Videos

Last Updated: May 5, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

12.8K
Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

9.7K
Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

14.5K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Proper cerebral cortex lamination relies on precisely orchestrated neuronal migration.
  • Failures or delays in neuronal migration are linked to disorders like lissencephaly, schizophrenia, autism, and mental retardation.
  • Neuronal migration is a dynamic process involving cytoskeletal remodeling.

Purpose of the Study:

  • To review the dynamic aspects of neuronal migration and brain development.
  • To describe the molecular and cellular mechanisms governing neuronal migration.
  • To elaborate on diseases associated with neuronal migration defects.

Main Methods:

  • Literature review focusing on dynamic aspects of neuronal migration.
  • Analysis of molecular and cellular mechanisms involved in neuronal migration.
  • Compilation of information on neuronal migration-related disorders.

Main Results:

  • Neuronal migration is a dynamic process essential for brain development.
  • Microtubules and associated proteins play significant roles in regulating neuronal migration.
  • Dysregulation of neuronal migration underlies various neurodevelopmental and psychiatric disorders.

Conclusions:

  • Understanding the dynamics and molecular mechanisms of neuronal migration is critical.
  • Further research into microtubule-related proteins may offer therapeutic insights for migration disorders.
  • Defects in neuronal migration contribute to a spectrum of significant neurological conditions.