Pseudocontinuous arterial spin labeling with prospective motion correction (PCASL-PROMO)

Area of Science:

• Medical Imaging
• Neuroimaging
• Biomedical Engineering

Background:

• Segmented 3D ASL perfusion imaging is increasingly used.
• Conventional motion correction methods are incompatible with segmented imaging.

Purpose of the Study:

• To integrate 3D pseudocontinuous ASL (PCASL) with PROMO (PROspective MOtion correction).
• To evaluate the effectiveness of PCASL-PROMO for cerebral blood flow (CBF) measurements.

Main Methods:

• PROMO was integrated into 3D PCASL without extending the repetition time.
• The system was tested with controlled and random motion using separate and interleaved scans.

Main Results:

• PROMO integration showed negligible difference (<0.2%) in average ASL signal.
• PROMO significantly reduced motion artifacts in both controlled and random motion scenarios.
• Real-time motion updating alone substantially reduced artifacts, with rescanning critical for tagged images.

Conclusions:

• PROMO is a successful motion correction strategy for PCASL CBF imaging.
• This integration enhances the reliability of perfusion measurements in challenging imaging conditions.