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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Mouse phenome database.

Stephen C Grubb¹, Carol J Bult, Molly A Bogue

¹The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA.

Nucleic Acids Research

|November 19, 2013

Summary

This summary is machine-generated.

The Mouse Phenome Database (MPD) now offers over 3500 quantitative phenotype measurements relevant to human health. Recent updates include new datasets, improved analysis tools, and enhanced genetic querying for mouse research.

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Area of Science:

Genomics
Bioinformatics
Mammalian Genetics

Background:

The Mouse Phenome Database (MPD) serves as a central data repository for the international Mouse Phenome Project.
It integrates diverse biological data types, including quantitative phenotypes, gene expression, and genotype information.
MPD aims to facilitate research into complex diseases and genetic influences.

Purpose of the Study:

To summarize recent data acquisitions and improvements to the Mouse Phenome Database.
To highlight the expansion of MPD's capabilities for querying and analyzing mouse genetic and phenotypic data.
To showcase new features enhancing data accessibility and research utility.

Main Methods:

Integration of over 70 new datasets, including data from Collaborative Cross and Diversity Outbred mice.
Revamping of the MPD homepage, search, and navigation functionalities.
Development of web-enabled data analysis and visualization tools, ontology annotation, and an ontology browser.
Implementation of enhanced single nucleotide polymorphism (SNP) query functionality with increased density coverage.

Main Results:

MPD now contains over 3500 phenotype measurements relevant to human health conditions such as cancer, aging, and cardiovascular disorders.
Significant improvements in user interface, search capabilities, and data analysis tools have been implemented.
Expanded genetic querying options provide higher density coverage for single nucleotide polymorphism analysis.

Conclusions:

The updated Mouse Phenome Database offers a more comprehensive and user-friendly platform for mouse genetic and phenotypic research.
Enhanced data integration and analysis tools facilitate deeper insights into genotype-phenotype relationships.
MPD continues to be a vital resource for studies relevant to human health and disease.