Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Comparison Tests01:13

Multiple Comparison Tests

3.5K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
3.5K
Structural Classification of Joints01:20

Structural Classification of Joints

8.0K
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
8.0K
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

2.0K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
2.0K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

11.6K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amorfrutin-A, a membrane-targeting phytochemical active against multidrug-resistant Staphylococcus aureus: In vitro and in vivo activity and mechanism of action.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Correction: The different affinity of the two metal-binding sites of human ferroportin drives outward directionality of transport.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2025
Same author

Discovery of new neutrophil elastase inhibitors through Meloidae genome and transcriptome analyses.

Bioorganic chemistry·2025
Same author

Horse heart mini- and full length-myoglobin: pH effects on CO binding.

Journal of inorganic biochemistry·2025
Same author

The different affinity of the two metal-binding sites of human ferroportin drives outward directionality of transport.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2025
Same author

Modeling the different conformations of the human mitochondrial ADP/ATP carrier using AlphaFold and molecular dynamics simulations of the protein-ligand complexes.

Computational and structural biotechnology journal·2025
Same journal

Cross-Domain Transfer Learning from Peptides to Metabolites Using a Multi-Property Fine-Tuned LLM.

Bioinformatics (Oxford, England)·2026
Same journal

Biomedical Concept Recognition with Error-aware Negative-enhanced Ranking Framework.

Bioinformatics (Oxford, England)·2026
Same journal

TEDLH: Domain HMMs for sensitive detection of remote homologues.

Bioinformatics (Oxford, England)·2026
Same journal

PLNFGL: Joint Estimation of Multi-Condition Gene Networks from Single-cell RNA-seq Data.

Bioinformatics (Oxford, England)·2026
Same journal

MCFST: Spatial domain identification method based on multi-view graph convolutional network and graph fusion network.

Bioinformatics (Oxford, England)·2026
Same journal

SpaBiT: Enhancing Spatial Transcriptomics Resolution via Bidirectional Attention Transformers.

Bioinformatics (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.2K

ASSIST: a fast versatile local structural comparison tool.

Silvia Caprari1, Daniele Toti, Le Viet Hung

  • 1Department of Sciences, University of Roma Tre, 00146 Rome, Department of Information and Electric Engineering and Applied Mathematics, University of Salerno, 84084 Fisciano, Italy, Artificial Solutions, 08026 Barcelona, Spain and National Institute of Nuclear Physics, Roma Tre Section, 00146 Rome, Italy.

Bioinformatics (Oxford, England)
|November 19, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a new tool that predicts protein catalytic function by comparing 3D structures. The algorithm accurately identifies protein functional classes using local structural similarity, aiding in the analysis of unknown proteins.

More Related Videos

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

3.8K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

1.3K

Related Experiment Videos

Last Updated: May 5, 2026

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.2K
Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

3.8K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

1.3K

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Structural genomics projects generate many protein structures with unknown functions.
  • Predicting protein function is crucial for understanding biological processes.

Purpose of the Study:

  • To develop a versatile tool for predicting protein catalytic function based on 3D structural similarity.
  • To address the challenge of assigning function to proteins with determined structures but unknown roles.

Main Methods:

  • Developed a novel algorithm based on local structural comparison.
  • Utilized a geometric hashing approach for efficient residue pair matching.
  • Implemented the tool in Java SE 6 with a Java Swing GUI.

Main Results:

  • The algorithm identifies the largest subset of similar residues between input proteins and known functional sites.
  • Tests demonstrated high accuracy in identifying the correct functional class for various proteins.
  • The tool successfully predicted the catalytic function for proteins from different functional classes.

Conclusions:

  • The developed tool is effective in predicting protein catalytic function from 3D structural data.
  • This method aids in assigning function to proteins identified through structural genomics.
  • The software is publicly available for local installation.