[Changes in axonal transport induced by ischemia]

Effect of ischemia, resulted from ligation of the abdominal part of the aorta, on the rate of anterograde and retrograde transport in the nervous pathways of the posterior roots has been studied in the canine spinal nerves. The anterograde transport rate is studied after injection of labelled 14C-leucine into spinal ganglia. An increased rate from 365 mm/day to 487 mm/day is revealed. The retrograde transport rate, that is estimated by means of horseradish peroxidase injected into the spinal cord, increases after the ischemia from 141 mm/day to 200 mm/day. A suggestion is made that the increase in the rate is caused by certain changes in ionic balance and osmosis produced by ischemia.