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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
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Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death

Karl J Wahlin1, Raymond A Enke, John A Fuller

  • 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Plos One
|November 19, 2013
PubMed
Summary

DNA methylation changes, including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), are linked to retinal neuron death during development and degeneration. These epigenetic modifications may regulate gene expression in retinal cell death processes.

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